May titrate to maximum of 19.2 mcg/day (0.8 mcg/hr). Indications and Dosages ▸ Pain Control Intrathecal Adults, Elderly. ![]() Excreted in urine as proteolytic degradation products. 50% bound to plasma proteins metabolized in multiple organs. Reduction of chronic pain in the body PharmacokineticsĮlimination Half-life: 4.6 hr after intrathecal administration. Therapeutic Effect: Blocks excitatory neurotransmitter release, reducing sensitivity to painful stimuli. ![]() ![]() ![]() In Mosby's Dental Drug Reference (Eleventh Edition), 2014 Drug Class:Ī synthetic peptide that selectively binds to and blocks N-type voltage-sensitive calcium channels located on afferent nerves in the spinal cord.
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